Blood Group-Specific Antibodies in Immune Hemolytic Anemia Induced by Nomifensine
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چکیده
Nomifensine (Mental. Alival; Hoechst. Frankfurt. FRG). an antidepressant drug. may cause immune hemolytic anemia (IHA) of the so-called immune complex type that is believed to occur by means of an innocent-bystander mechanism. In this report we describe findings that are not consistent with this mechanism in a patient with nomifensine-induced intravascular IHA associated with renal failure. In vitro studies showed a transitory positive direct antiglobulin test (DAT) due to lgG. 1gM. and C3 fixation. The causative antibodies were found to be (1 ) a drug-independent 1gM antibody in the serum and eluate that reacted only with E-positive RBC. although the patient’s RBC were Enegative; (2) an lgG antibody in the serum and initial eluates that showed a stronger reaction with e-positive than with e-negative or Rh,... RBC. but only in the presence of ex vivo antigen (ie. urine containing the drug and all its metabolities); and (3) an 1gM antibody in the serum and
منابع مشابه
On the mechanisms of sensitization and attachment of antibodies to RBC in drug-induced immune hemolytic anemia.
The mechanisms of sensitization and attachment of drug-dependent antibodies to RBC in drug-induced immune hemolytic anemias are largely speculative. Nomifensine has been incriminated in causing immune hemolysis in a large number of patients. The hemolysis was usually of the so-called immune complex type, less commonly of the autoimmune type, and more surprisingly, few patients had developed bot...
متن کاملRh blood group-specific antibodies in immune hemolytic anemia induced by nomifensine.
Nomifensine (Merital, Alival; Hoechst, Frankfurt, FRG), an antidepressant drug, may cause immune hemolytic anemia (IHA) of the so-called immune complex type that is believed to occur by means of an innocent-bystander mechanism. In this report we describe findings that are not consistent with this mechanism in a patient with nomifensine-induced intravascular IHA associated with renal failure. In...
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The mechanisms of sensitization and attachment of drugdependent antibodies to RBC in drug-induced immune hemolytic anemias are largely speculative. Nomifensine has been incriminated in causing immune hemolysis in a large number of patients. The hemolysis was usually of the so-called immune complex type, less commonly of the autoimmune type, and more surprisingly. few patients had developed both...
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